Layout design is a crucial step in developing mobile app pages. However, crafting satisfactory designs is time-intensive for designers: they need to consider which controls and content to present on the page, and then repeatedly adjust their size, position, and style for better aesthetics and structure. Although many design software can now help to perform these repetitive tasks, extensive training is needed to use them effectively. Moreover, collaborative design across app pages demands extra time to align standards and ensure consistent styling. In this work, we propose APD-agents, a large language model (LLM) driven multi-agent framework for automated page design in mobile applications. Our framework contains OrchestratorAgent, SemanticParserAgent, PrimaryLayoutAgent, TemplateRetrievalAgent, and RecursiveComponentAgent. Upon receiving the user's description of the page, the OrchestratorAgent can dynamically can direct other agents to accomplish users' design task. To be specific, the SemanticParserAgent is responsible for converting users' descriptions of page content into structured data. The PrimaryLayoutAgent can generate an initial coarse-grained layout of this page. The TemplateRetrievalAgent can fetch semantically relevant few-shot examples and enhance the quality of layout generation. Besides, a RecursiveComponentAgent can be used to decide how to recursively generate all the fine-grained sub-elements it contains for each element in the layout. Our work fully leverages the automatic collaboration capabilities of large-model-driven multi-agent systems. Experimental results on the RICO dataset show that our APD-agents achieve state-of-the-art performance.

Recent advancements in Large Vision-Language Models are accelerating the development of Graphical User Interface (GUI) agents that utilize human-like vision perception capabilities to enhance productivity on digital devices. Compared to approaches predicated on GUI metadata, which are platform-dependent and vulnerable to implementation variations, vision-based approaches offer broader applicability. In this vision-based paradigm, the GUI instruction grounding, which maps user instruction to the location of corresponding element on the given screenshot, remains a critical challenge, particularly due to limited public training dataset and resource-intensive manual instruction data annotation. In this paper, we delve into unexplored challenges in this task including element-to-screen ratio, unbalanced element type, and implicit instruction. To address these challenges, we introduce a large-scale data synthesis pipeline UI-E2I-Synth for generating varying complex instruction datasets using GPT-4o instead of human annotators. Furthermore, we propose a new GUI instruction grounding benchmark UI-I2E-Bench, which is designed to address the limitations of existing benchmarks by incorporating diverse annotation aspects. Our model, trained on the synthesized data, achieves superior performance in GUI instruction grounding, demonstrating the advancements of proposed data synthesis pipeline. The proposed benchmark, accompanied by extensive analyses, provides practical insights for future research in GUI grounding. We will release corresponding artifacts at https://microsoft.github.io/FIVE-UI-Evol/ .

Deep generative models have achieved tremendous success in designing novel drug molecules in recent years. A new thread of works have shown the great potential in advancing the specificity and success rate of in silico drug design by considering the structure of protein pockets. This setting posts fundamental computational challenges in sampling new chemical compounds that could satisfy multiple geometrical constraints imposed by pockets. Previous sampling algorithms either sample in the graph space or only consider the 3D coordinates of atoms while ignoring other detailed chemical structures such as bond types and functional groups. To address the challenge, we develop Pocket2Mol, an E(3)-equivariant generative network composed of two modules: 1) a new graph neural network capturing both spatial and bonding relationships between atoms of the binding pockets and 2) a new efficient algorithm which samples new drug candidates conditioned on the pocket representations from a tractable distribution without relying on MCMC. Experimental results demonstrate that molecules sampled from Pocket2Mol achieve significantly better binding affinity and other drug properties such as druglikeness and synthetic accessibility.

In poster design, content-aware layout generation is crucial for automatically arranging visual-textual elements on the given image. With limited training data, existing work focused on image-centric enhancement. However, this neglects the diversity of layouts and fails to cope with shape-variant elements or diverse design intents in generalized settings. To this end, we proposed a layout-centric approach that leverages layout knowledge implicit in large language models (LLMs) to create posters for omnifarious purposes, hence the name PosterO. Specifically, it structures layouts from datasets as trees in SVG language by universal shape, design intent vectorization, and hierarchical node representation. Then, it applies LLMs during inference to predict new layout trees by in-context learning with intent-aligned example selection. After layout trees are generated, we can seamlessly realize them into poster designs by editing the chat with LLMs. Extensive experimental results have demonstrated that PosterO can generate visually appealing layouts for given images, achieving new state-of-the-art performance across various benchmarks. To further explore PosterO's abilities under the generalized settings, we built PStylish7, the first dataset with multi-purpose posters and various-shaped elements, further offering a challenging test for advanced research.

Large vision language models (LVLMs) have improved the document understanding capabilities remarkably, enabling the handling of complex document elements, longer contexts, and a wider range of tasks. However, existing document understanding benchmarks have been limited to handling only a small number of pages and fail to provide a comprehensive analysis of layout elements locating. In this paper, we first define three primary task categories: Long Document Understanding, numerical Reasoning, and cross-element Locating, and then propose a comprehensive benchmark, LongDocURL, integrating above three primary tasks and comprising 20 sub-tasks categorized based on different primary tasks and answer evidences. Furthermore, we develop a semi-automated construction pipeline and collect 2,325 high-quality question-answering pairs, covering more than 33,000 pages of documents, significantly outperforming existing benchmarks. Subsequently, we conduct comprehensive evaluation experiments on both open-source and closed-source models across 26 different configurations, revealing critical performance gaps in this field.

Chunking information is a key step in Retrieval Augmented Generation (RAG). Current research primarily centers on paragraph-level chunking. This approach treats all texts as equal and neglects the information contained in the structure of documents. We propose an expanded approach to chunk documents by moving beyond mere paragraph-level chunking to chunk primary by structural element components of documents. Dissecting documents into these constituent elements creates a new way to chunk documents that yields the best chunk size without tuning. We introduce a novel framework that evaluates how chunking based on element types annotated by document understanding models contributes to the overall context and accuracy of the information retrieved. We also demonstrate how this approach impacts RAG assisted Question & Answer task performance. Our research includes a comprehensive analysis of various element types, their role in effective information retrieval, and the impact they have on the quality of RAG outputs. Findings support that element type based chunking largely improve RAG results on financial reporting. Through this research, we are also able to answer how to uncover highly accurate RAG.

They have shown a promising prospect in automatically completing tasks upon user instructions, functioning as brain-like coordinators. The associated risks will be revealed as we delegate an increasing number of tasks to machines for automated completion. A big question emerges: how can we make machines behave responsibly when helping humans automate tasks as personal copilots? In this paper, we explore this question in depth from the perspectives of feasibility, completeness and security. In specific, we present Responsible Task Automation (ResponsibleTA) as a fundamental framework to facilitate responsible collaboration between LLM-based coordinators and executors for task automation with three empowered capabilities: 1) predicting the feasibility of the commands for executors; 2) verifying the completeness of executors; 3) enhancing the security (e.g., the protection of users' privacy). We further propose and compare two paradigms for implementing the first two capabilities. One is to leverage the generic knowledge of LLMs themselves via prompt engineering while the other is to adopt domain-specific learnable models. Moreover, we introduce a local memory mechanism for achieving the third capability. We evaluate our proposed ResponsibleTA on UI task automation and hope it could bring more attentions to ensuring LLMs more responsible in diverse scenarios.

Zero-shot information extraction (IE) aims to build IE systems from the unannotated text. It is challenging due to involving little human intervention. Challenging but worthwhile, zero-shot IE reduces the time and effort that data labeling takes. Recent efforts on large language models (LLMs, e.g., GPT-3, ChatGPT) show promising performance on zero-shot settings, thus inspiring us to explore prompt-based methods. In this work, we ask whether strong IE models can be constructed by directly prompting LLMs. Specifically, we transform the zero-shot IE task into a multi-turn question-answering problem with a two-stage framework (ChatIE). With the power of ChatGPT, we extensively evaluate our framework on three IE tasks: entity-relation triple extract, named entity recognition, and event extraction. Empirical results on six datasets across two languages show that ChatIE achieves impressive performance and even surpasses some full-shot models on several datasets (e.g., NYT11-HRL). We believe that our work could shed light on building IE models with limited resources.

Generating molecules that bind to specific proteins is an important but challenging task in drug discovery. Previous works usually generate atoms in an auto-regressive way, where element types and 3D coordinates of atoms are generated one by one. However, in real-world molecular systems, the interactions among atoms in an entire molecule are global, leading to the energy function pair-coupled among atoms. With such energy-based consideration, the modeling of probability should be based on joint distributions, rather than sequentially conditional ones. Thus, the unnatural sequentially auto-regressive modeling of molecule generation is likely to violate the physical rules, thus resulting in poor properties of the generated molecules. In this work, a generative diffusion model for molecular 3D structures based on target proteins as contextual constraints is established, at a full-atom level in a non-autoregressive way. Given a designated 3D protein binding site, our model learns the generative process that denoises both element types and 3D coordinates of an entire molecule, with an equivariant network. Experimentally, the proposed method shows competitive performance compared with prevailing works in terms of high affinity with proteins and appropriate molecule sizes as well as other drug properties such as drug-likeness of the generated molecules.

At Apple we use machine learning to teach our products to understand the world more as humans do. Of course, understanding the world better means building great assistive experiences. Machine learning can help our products be intelligent and intuitive enough to improve the day-to-day experiences of people living with disabilities. We can build machine-learned features that support a wide range of users including those who are blind or have low vision, those who are deaf or are hard of hearing, those with physical motor limitations, and also support those with cognitive disabilities. Mobile devices and their apps have become ubiquitous.